# Lanthanide catalysts enable one-step synthesis of complex drug precursors

**URL:** <https://community.materialssquare.com/t/lanthanide-catalysts-enable-one-step-synthesis-of-complex-drug-precursors/431>\
**Category:** News\
**Created:** [June 25, 2024, 11:21am UTC](https://community.materialssquare.com/t/lanthanide-catalysts-enable-one-step-synthesis-of-complex-drug-precursors/431 "2024-06-25T11:21:30Z")\
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**Author:** ![gabriele1](https://yyz1.discourse-cdn.com/flex003/user_avatar/community.materialssquare.com/gabriele1/32/20_2.png) [@gabriele1](https://community.materialssquare.com/u/gabriele1)\
**Post date:** [June 25, 2024, 11:21am UTC](https://community.materialssquare.com/t/lanthanide-catalysts-enable-one-step-synthesis-of-complex-drug-precursors/431/1 "2024-06-25T11:21:30Z")

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Researchers from Chiba University have developed a new lanthanide-based catalyst that enables the one-step synthesis of complex drug precursors, such as hydrocarbazole compounds. This method, utilizing a chiral holmium triflimide catalyst, significantly improves yield and enantioselectivity, achieving up to 95% yield. The catalyst is also recyclable, promoting sustainable chemical processes. This breakthrough facilitates the creation of biologically active compounds for pharmaceuticals, including anticancer and anti-inflammatory drugs, potentially accelerating drug development and improving global health outcomes.

For more details, read the full article here:

> **[Lanthanide catalysts enable one-step synthesis of complex drug precursors](https://phys.org/news/2024-06-lanthanide-catalysts-enable-synthesis-complex.html)**
>
> Hydrocarbazole is a crucial compound in organic chemistry, serving as a building block for various biologically active compounds, including pesticides such as strychnine and anticancer drugs such as vinblastine and minovincine. Consequently, the...