Researchers from the VIB-VUB Center for Structural Biology and the University of Washington have developed a new approach for designing transmembrane β-barrel (TMB) nanopores. These synthetic nanopores have customizable shapes and properties, enhancing their stability and conductance. This advancement allows for the creation of nanopores tailored for single-molecule analytics, such as DNA and RNA sequencing, outside specialized labs. The breakthrough paves the way for portable devices capable of detecting small molecules and performing biomolecular sequencing, complementing existing large-scale analytical methods.
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