This article details groundbreaking research from Ludwig Maximilian University of Munich on cationic polymers used as “gene ferries” for transporting RNA therapeutics and vaccines. These polymers, akin to lipid nanocarriers, protect RNA and deliver it to target cells. The study, led by Professor Olivia Merkel, investigates the molecular organization of these nanocarriers to optimize their performance. Using coarse-grained molecular dynamics (CG-MD) simulations and nuclear magnetic resonance (NMR) experiments, the researchers analyzed how changes in polymer structure and environmental conditions affect RNA encapsulation and release. The findings, published in Nano Letters, provide critical insights for designing more effective RNA delivery systems, advancing the field of RNA-based medicine.
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