Researchers from the Chinese Academy of Sciences have developed single-atom nanozymes with an axial oxygen atom-modified Fe-N₄ structure to improve singlet oxygen (¹O₂) production under hypoxic conditions, which is crucial for cancer therapies. These nanozymes enhance the efficiency of the Russell reaction, generating ¹O₂ without external stimuli. The new nanozymes demonstrate self-cascade enzymatic activity, effectively inhibiting triple-negative breast cancer cell proliferation by reducing glutathione peroxidase 4 and increasing lipid peroxidation. This discovery offers a promising strategy for advanced tumor therapies.
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