Scientists from the Chinese Academy of Sciences have developed a high-efficiency antimicrobial nanozyme that mimics the functions of antimicrobial peptides (AMPs) and enzymes (AMEs). This dual-functional nanozyme, called Ni-IH-7, is created through peptide self-assembly and metal coordination. It exhibits strong fungicidal activity by binding to the mannoprotein on Candida albicans, leading to lipid peroxidation and rapid fungal death. The nanozyme also shows good resistance to hydrolytic enzymes and effective antifungal performance in clinical tests, offering a promising strategy for developing novel antimicrobial drugs.
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