Researchers at the University of Chemistry and Technology in Prague have developed a method using chiral high-performance liquid chromatography (HPLC) with circular dichroism (CD) detection to identify the absolute configuration of psychoactive cathinones, synthetic compounds with stimulant effects. Led by Prof. Michal Kohout, the study synthesized new α-tetralone-based cathinone derivatives, analyzing their chiral structures using HPLC and density functional theory (DFT) for precise structural data. This methodology offers critical accuracy in characterizing these compounds’ 3D conformations, enhancing regulatory categorization and potential pharmaceutical applications. This approach could streamline legal processes by providing authorities with reliable data on these new psychoactive substances.
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