Researchers from Chiba University have developed a new lanthanide-based catalyst that enables the one-step synthesis of complex drug precursors, such as hydrocarbazole compounds. This method, utilizing a chiral holmium triflimide catalyst, significantly improves yield and enantioselectivity, achieving up to 95% yield. The catalyst is also recyclable, promoting sustainable chemical processes. This breakthrough facilitates the creation of biologically active compounds for pharmaceuticals, including anticancer and anti-inflammatory drugs, potentially accelerating drug development and improving global health outcomes.
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